Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Mar 30;31(13):4768-70.
doi: 10.1523/JNEUROSCI.6612-10.2011.

Lactate transport and metabolism in the human brain: implications for the astrocyte-neuron lactate shuttle hypothesis

Chase R Figley  1
Affiliations
Comment

Lactate transport and metabolism in the human brain: implications for the astrocyte-neuron lactate shuttle hypothesis

Chase R Figley. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The cerebral metabolic rate of plasma-borne lactate as a function of brain lactate concentration. The dashed line represents the least-squares linear regression CMRlac = 0.023[Lac]B, which yields an R2 = 0.23, or 0.40 by including a point at the origin. Data were generously supplied by Boumezbeur et al. (2010).
See this image and copyright information in PMC

Comment on

References

    1. Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol. 2009;513:532–541. - PubMed
    1. Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, Rothman DL. The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci. 2010;30:13983–13991. - PMC - PubMed
    1. Caesar K, Hashemi P, Douhou A, Bonvento G, Boutelle MG, Walls AB, Lauritzen M. Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum in vivo. J Physiol. 2008;586:1337–1349. - PMC - PubMed
    1. Figley CR, Stroman PW. The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals. Eur J Neurosci. 2011;33:577–588. - PubMed
    1. Gandhi GK, Cruz NF, Ball KK, Dienel GA. Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons. J Neurochem. 2009;111:522–536. - PMC - PubMed

LinkOut - more resources