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. 2011 Mar 30;3(76):76ps10.
doi: 10.1126/scitranslmed.3000996.

Human pluripotent stem cells: decoding the naïve state

Wenlin Li  1 , Sheng Ding
Affiliations

Human pluripotent stem cells: decoding the naïve state

Wenlin Li et al. Sci Transl Med. .

Abstract

Human pluripotent stem cells play a central role in regenerative medicine and tissue engineering. These versatile cells can exist in a range of manipulable states with distinct functionalities, from the late epiblast stage represented by the conventional human embryonic stem cells (hESCs) to the mouse ESC-like naïve state. These functional states must be fully characterized if we are to harness the power of pluripotent stem cells to transform clinical medicine and therapeutics discovery.

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