Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Apr 12;108(15):5929-30.
doi: 10.1073/pnas.1103102108. Epub 2011 Mar 30.

Winning WNT: race to Wnt signaling inhibitors

Kazuhide Watanabe  1 , Xing Dai
Affiliations
Comment

Winning WNT: race to Wnt signaling inhibitors

Kazuhide Watanabe et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The Wnt/β-catenin signaling pathway and its small molecule inhibitors. Binding of a Wnt ligand to membrane receptor/coreceptor triggers an intracellular signaling cascade leading to the stabilization and nuclear translocation of β-catenin. β-catenin in the nucleus binds to T cell factor (TCF)/lymphoid enhancer factor (LEF) and a number of cofactors to regulate gene expression. Red and green arrows indicate events that negatively and positively, respectively, affect signaling output. Examples of recently discovered small molecule inhibitors are shown, with their sites of action detailed in the table below the diagram.
See this image and copyright information in PMC

Comment on

References

    1. Nusse R, van Ooyen A, Cox D, Fung YK, Varmus H. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature. 1984;307:131–136. - PubMed
    1. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996;87:159–170. - PubMed
    1. Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8:387–398. - PubMed
    1. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127:469–480. - PubMed
    1. Ying Y, Tao Q. Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics. 2009;4:307–312. - PubMed

Publication types

LinkOut - more resources