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. 2011 Apr;17(4):HY1-4.
doi: 10.12659/msm.881698.

A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution

Yunhai Chuai  1 , Luqian Zhao, Jin Ni, Ding Sun, Jianguo Cui, Bailong Li, Liren Qian, Fu Gao, Jianming Cai
Affiliations

A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution

Yunhai Chuai et al. Med Sci Monit. 2011 Apr.

Abstract

Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, we hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen-rich solution such as physiological saline saturated with molecular hydrogen is safer).<br />

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References

    1. Woltman NM, Garces Y, Olivier K, Miller R. Incidence of radiation pneumonitis after thoracic intensity modulated radiation therapy. Int J Radiation Oncology Biol Phy. 2010;78:S738.
    1. Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007;13:688–94. - PubMed
    1. Yanfei M, Xingfeng Z, Jianmei C. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commum. 2009;381:602–5. - PubMed
    1. Liren Q, Fei C, Jianguo C. Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res. 2010;44:275–82. - PubMed
    1. Liren Q, Bailong L, Fei C, et al. Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection. 2010;25:23–29.

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