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Review
. 2011 Mar 18;13(2):208.
doi: 10.1186/ar3255.

The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies

Nadia Sassi  1 , Lilia Laadhar, Maha Driss, Meriam Kallel-Sellami, Slaheddine Sellami, Sondes Makni
Affiliations
Review

The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies

Nadia Sassi et al. Arthritis Res Ther. .

Abstract

Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we report on studies that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of chondrocytes. Temporal and/or spatial modulation of this signaling pathway may help these cells to synthesize a new functional extracellular matrix and restore the functional properties of the articular cartilage.

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Figures

Figure 1
Figure 1
The main components of the Notch receptor and its ligands in mammals.
Figure 2
Figure 2
Canonical and non-canonical (Abl) Notch signaling pathways. A, co-activator; CSL, CBF, Su(H), Lag3; DSL, Delta, Serrate, Lag2; R, co-repressor; S1, S2, S3 and S4, Notch cleavage sites in the canonical signaling pathway; TACE, tumor necrosis factor alpha converting enzyme.
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References

    1. Kouri JB, Lavalle C. Do chondrocytes undergo activation and transdifferentiation during the pathogenesis of osteoarthritis? A review of the ultrastructural and immunohistochemical evidence. Histol Histopathol. 2006;21:793–802. - PubMed
    1. Cai SA, Fu X, Sheng Z. Dedifferentiation: a new approach in stem cell research. Bioscience. 2007;57:655–662. doi: 10.1641/B570805. - DOI
    1. Greenberg DA, Jin K. Turning neurogenesis up a Notch. Nat Med. 2006;12:884–885. doi: 10.1038/nm0806-884. - DOI - PubMed
    1. Yoon K, Gaiano N. Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci. 2005;8:709–715. doi: 10.1038/nn1475. - DOI - PubMed
    1. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg HM, Scadden DT. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425:841–846. doi: 10.1038/nature02040. - DOI - PubMed

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