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Review
. 2011 Dec 1;717(1-2):1-8.
doi: 10.1016/j.mrfmmm.2011.03.009. Epub 2011 Mar 30.

MicroRNA history: discovery, recent applications, and next frontiers

Maria I Almeida  1 , Rui M Reis, George A Calin
Affiliations
Review

MicroRNA history: discovery, recent applications, and next frontiers

Maria I Almeida et al. Mutat Res. .

Abstract

Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addition, we examine microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets.

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