Review
doi: 10.1016/0167-5699(90)90142-v.
Cognate interactions between helper T cells and B cells
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- PMID: 2145852
- DOI: 10.1016/0167-5699(90)90142-v
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Review
Cognate interactions between helper T cells and B cells
Immunol Today.
1990 Oct.
Abstract
The mechanism by which mammals produce an antibody response after exposure to antigen has intrigued biologists for over a hundred years. Here, Randolph Noelle and Charles Snow review some of the experimental findings since the early 1970s that have advanced understanding of the mechanisms operating during B-cell activation by thymus-dependent (TD) antigens. They also propose a model for B-cell activation that emphasizes the critical role played by direct cellular interactions between B cells and helper T(TH) cells and seek to place into perspective the role played by the membrane immunoglobulin (mlg) receptor in cognate responses.
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