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. 2011 Apr;204(4):330.e1-4.
doi: 10.1016/j.ajog.2011.01.049.

Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance

Kiran B Tam Tam  1 , Eric George, Kathy Cockrell, Marietta Arany, Joshua Speed, James N Martin Jr, Babbette Lamarca, Joey P Granger
Affiliations

Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance

Kiran B Tam Tam et al. Am J Obstet Gynecol. 2011 Apr.

Abstract

Objective: We sought to determine the effect of an endothelin type A receptor antagonist (ETA) on uterine artery resistive index (UARI) and mean arterial pressure (MAP) in a placental ischemia rat model of preeclampsia produced by reduction in uterine perfusion pressure (RUPP).

Study design: UARI was assessed by Doppler velocimetry in RUPP and normal pregnant controls (NP) on gestational days (GD) 12, 15, and 18. UARI was also determined on GD 18 in NP and RUPP pregnant dams after pretreatment with ETA. MAP was recorded on GD 19.

Results: The RUPP group had a higher MAP and UARI on GD 15 and 18 than the NP group. Pretreatment with ETA attenuated both the MAP and GD-18 UARI in the RUPP group without affecting these parameters in the NP group.

Conclusion: The improvement in UARI could be one potential mechanism for the reduction in MAP in response to ETA in pregnant dams with ischemic placentas.

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Figures

Figure I
Figure I
(a): Uterine artery resistive index changes by gestation day (GD) in NP and RUPP dams. All data are expressed as mean ±SEM. +P <0.05 vs. NP GD 12, NP GD 15, NP GD18 and RUPP GD 12. ±P <0.05 vs. NP GD 12, NP GD 18 and RUPP GD12. (b): Uterine artery resistive index and mean arterial blood pressure in NP and RUPP dams with and without ETA pretreatment. All data are expressed as mean ±SEM. *P <0.05 vs. NP, NP/ETA and RUPP/ETA. †P <0.05 vs. NP, NP/ETA, RUPP/ETA. ‡P <0.05 vs. NP, NP/ETA and RUPP.
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