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Comment
. 2011 Apr 1;145(1):13-4.
doi: 10.1016/j.cell.2011.02.041.

Directly observing therapy: a new view of drug tolerance in tuberculosis

Jennifer A Philips  1 , Joel D Ernst
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Directly observing therapy: a new view of drug tolerance in tuberculosis

Jennifer A Philips et al. Cell. .
Free article

Abstract

Drug tolerance in bacteria is widely believed to be due to metabolic changes that accompany growth arrest. A study in this issue of Cell reveals a drug tolerance mechanism in replicating mycobacteria that is induced by residence in macrophages and depends on drug efflux.

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