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. 1990;26(8):905-7.
doi: 10.1016/0277-5379(90)90197-2.

Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines

J Nordenberg  1 , A Novogrodsky, E Beery, M Patia, L Wasserman, A Warshawsky
Affiliations

Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines

J Nordenberg et al. Eur J Cancer. 1990.

Abstract

The effect of the transition metal chelator, 8-hydroxyquinoline (8-HQ), was examined on the growth and phenotype expression of B16 mouse melanoma cells. Micromolar concentrations of 8-HQ inhibited the growth of B16 cells as well as human melanoma cell lines. Removal of 8-HQ from the culture medium restored normal cell growth. Growth inhibition by 8-HQ was accompanied by phenotypic alterations that included changes in cell morphology, increased production of melanin and enhanced activities of the enzymes gamma-glutamyl transpeptidase and NADPH cytochrome c reductase. These changes might be associated with a better differentiated phenotype.

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