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Review
. 2011 Apr;78(4):243-57.
doi: 10.3949/ccjm.78a.10145.

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others

Joseph P Kitzmiller  1 , David K Groen, Mitch A Phelps, Wolfgang Sadee
Affiliations
Review

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others

Joseph P Kitzmiller et al. Cleve Clin J Med. 2011 Apr.

Abstract

Genetics may account for much of the variability in our patients' responses to drug therapies. This article offers the clinician an up-to-date overview of pharmacogenomic testing, discussing implications and limitations of emerging validated tests relevant to the use of warfarin (Coumadin), clopidogrel (Plavix), statins, tamoxifen (Nolvadex), codeine, and psychotropic drugs. It also discusses the future role of pharmacogenomic testing in medicine.

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Figures

FIGURE 1
FIGURE 1
How a genetic test becomes a standard of care: Typical advancement pathway
FIGURE 2
FIGURE 2
Why some drugs don’t work in some patients
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