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. 2011 May;7(5):260-2.
doi: 10.1038/nchembio.551. Epub 2011 Apr 3.

Cholesterol modulates glycolipid conformation and receptor activity

Daniel Lingwood  1 , Beth Binnington, Tomasz Róg, Ilpo Vattulainen, Michal Grzybek, Unal Coskun, Clifford A Lingwood, Kai Simons
Affiliations

Cholesterol modulates glycolipid conformation and receptor activity

Daniel Lingwood et al. Nat Chem Biol. 2011 May.

Abstract

We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.

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References

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