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. 2011 Apr;3(2):128-31.
doi: 10.4168/aair.2011.3.2.128. Epub 2010 Sep 6.

Two cases of h(2)-receptor antagonist hypersensitivity and cross-reactivity

Woo-Jung Song  1 , Min-Hye Kim, Sang-Min Lee, Yong-Eun Kwon, Sae-Hoon Kim, Sang-Heon Cho, Kyung-Up Min, You-Young Kim, Yoon-Seok Chang
Affiliations

Two cases of h(2)-receptor antagonist hypersensitivity and cross-reactivity

Woo-Jung Song et al. Allergy Asthma Immunol Res. 2011 Apr.

Abstract

H(2)-receptor antagonists, such as cimetidine, ranitidine and famotidine, are some of the most commonly prescribed medications for gastric acid-related disorders. These compounds are generally well-tolerated and anaphylactic reactions to them are rare. Here, we report two cases of H(2)-receptor antagonist-induced anaphylactic reactions: the first presented with sudden dyspnea, sneezing, urticaria, and swelling of the eyelids after ranitidine intake. The second presented with sudden severe urticaria, facial swelling, chest discomfort, dizziness, and hypotension. Possible cross-reactivity with other H(2)-receptor antagonists was assessed by oral challenge and skin tests. To date, only a few reports addressing cross-reactivity among H(2)-receptor antagonists have been published. We review the literature and summarize the data available on drug cross-reactivity in H(2)-receptor antagonist hypersensitivity.

Keywords: Histamine H2 receptor antagonists; allergy; cross reactions; drug hypersensitivity.

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Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

Figures

Figure
Figure
Chemical structures of H2-receptor antagonists.
See this image and copyright information in PMC

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