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. 2011 Jan 12:6:1-6.
doi: 10.4137/BMI.S6150.

Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels During Normal Pregnancy

Abdolreza Sotoodeh Jahromi  1 , Parvin Zareian, Abdolhossein Madani
Affiliations

Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels During Normal Pregnancy

Abdolreza Sotoodeh Jahromi et al. Biomark Insights. .

Abstract

Overview: The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy.

Approach: This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method.

Results: There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women.

Conclusion: In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.

Keywords: IL-6; TNF-α; body mass index; gestational age; insulin resistance; normal pregnancy.

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Figures

Figure 1
Figure 1
A) BMI in patients in different trimesters of pregnancy and non pregnant subjects. BMI were significantly higher in 3rd trimesters compared with the control (**P < 0.01). B) Systolic blood pressure in different trimesters of pregnancy and non pregnant subjects. B) Systolic blood pressure was significantly higher in the 2nd and 3rd trimesters as compared with non pregnant subjects (*P < 0.05; **P < 0.01). C) Serum IL-6 level in different trimesters of pregnancy and non pregnant subjects. Serum IL-6 level was significantly higher in the 1st, 2nd and 3rd trimester as compared with non pregnant subjects (*P < 0.05). D) Serum TNF level in different trimesters of pregnancy and non pregnant subjects. TNF level was significantly higher in the 1st, 2nd and 3rd trimesters of pregnancy as compared non pregnant subjects (***P < 0.0001; **P < 0.01).
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