Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Oct 15;46(10):993-9.
doi: 10.1007/BF01940652.

A unifying model of the cell proliferation emphasizing plasma membrane fluxes

A unifying model of the cell proliferation emphasizing plasma membrane fluxes

E Cervén. Experientia. .

Abstract

The regulation of cellular growth and proliferation is perhaps the most investigated and elusive problem in cell biology and seems to be possible to solve from almost any angle of study chosen. Among the non-systemic factors that have been discussed are genetic damage, genomic control, regulation by stimulatory and inhibitory peptide factors such as EGF, chalones, and fibronectin, protein kinase activation with tyrosine phosphorylation, adenylylcyclase and cAMP, cGMP, membrane perturbations and specifically in tumours the failure of the Pasteur effect in control of glycolysis, excessive membrane ATPase activity, and excessive hydrolytic and proteolytic activities at the cell surface. This article focuses on the central role of fluxes within the plasma membrane and re-examines the possibility that changes of flux of metabolites, ions, and reducing equivalents may be the common denominator regulating cellular proliferation.

PubMed Disclaimer

Similar articles

References

    1. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4090-4 - PubMed
    1. Nature. 1970 Nov 7;228(5271):512-5 - PubMed
    1. Cancer Res. 1988 Apr 1;48(7):1792-7 - PubMed
    1. J Cell Physiol Suppl. 1987;Suppl 5:69-73 - PubMed
    1. Biochim Biophys Acta. 1974 Nov 6;366(4):402-10 - PubMed

Substances