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. 2009 Sep;3(5):223-31.
doi: 10.1111/j.1750-2659.2009.00093.x.

Estimates of the impact of a future influenza pandemic in China

Hongjie Yu  1 , Luzhao Feng, Zhibin Peng, Zijian Feng, David K Shay, Weizhong Yang
Affiliations

Estimates of the impact of a future influenza pandemic in China

Hongjie Yu et al. Influenza Other Respir Viruses. 2009 Sep.

Abstract

Background: The next influenza pandemic will create a surge in demand for health resources in China, with its current population of >1·3 billion persons and under-developed medical care and public health system. However, few pandemic impact data are available for China.

Objectives: We estimated the effects of a future influenza pandemic in China by examining pandemic scenarios of varying severity and described the time distribution of cases during a first wave.

Methods: We used a Monte-Carlo simulation model and death rates, hospitalizations and outpatient visits for 1918- and 1968- like pandemic scenarios and data from the literature or experts' opinion to estimate four health outcomes: deaths, hospitalizations, outpatient medical visits and clinical illness for which medical care was not sought. For each of the two scenarios we estimated outcomes by week using a normal distribution.

Results: We estimated that a 1968 scenario in China would result in 460,000-700,000 deaths, 1·94-2·27 million hospitalizations, 111-117 million outpatient visits and 192-197 million illnesses for which medical care was not sought. Fifty-two percent of hospitalizations occurred during the two-peak weeks of the first wave. We estimated that patients at high-risk of influenza complications (10-17% of the population) would account for 61-75% of all deaths. For a 1918 scenario, we estimated that 4·95-6·95 million deaths, 20·8-22·7 million hospitalizations and 101-108 million outpatient visits could occur.

Conclusion: Even a 1968 pandemic scenario will pose substantial challenges for the medical and public health system in China, and planning to manage these challenges is essential.

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Figures

Figure 1
Figure 1
Time distribution of cases during 8 weeks in a 1968‐type pandemic in China. Panel A: lower estimate for AR; panel B: upper estimate for AR.
Figure 2
Figure 2
Time distribution of cases during 8 weeks in a 1918‐type pandemic in China. Panel A: lower estimate for AR; panel B: upper estimate for AR.
See this image and copyright information in PMC

References

    1. World Health Organization . Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO. Available at http://www.who.int/csr/disease/avian_influenza/country/cases_table_2009_... (Accessed 25 April 2009).
    1. Horimoto T, Kawaoka Y. Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol 2005; 3:591–600. - PubMed
    1. Lanford C. Did the 1918–19 influenza pandemic originate in China? Popul dev rev 2005; 31:473–505.
    1. Patriarca PA, Cox NJ. Influenza pandemic preparedness plan for the United States. J Infect Dis 1997; 176(Suppl 1):S4–S7. - PubMed
    1. Webster RG. Predictions for future human influenza pandemics. J Infect Dis 1997; 176(Suppl 1):S14–S19. - PubMed

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