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Review
. 2011 Mar-Apr;26(2):73-87.
doi: 10.1177/0885066610384188.

Interleukin-6 in surgery, trauma, and critical care part II: clinical implications

Randeep S Jawa  1 , Sergio Anillo, Kristin Huntoon, Heinz Baumann, Mahmoud Kulaylat
Affiliations
Review

Interleukin-6 in surgery, trauma, and critical care part II: clinical implications

Randeep S Jawa et al. J Intensive Care Med. 2011 Mar-Apr.

Abstract

A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.

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Conflict of interest statement

Declaration of Conflicting Interests

The author(s) declared no conflicts of interest with respect to the authorship and/or publication of this article.

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