Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;36(3):203-11.
doi: 10.3969/j.issn.1672-7347.2011.03.003.

Expression of cyclophilin A and CD147 during skin aging

Ji Li  1 , Hongfu Xie, Mei Yi, Lefang Peng, Dan Lei, Xiang Chen, Dan Jian
Affiliations

Expression of cyclophilin A and CD147 during skin aging

Ji Li et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Mar.

Abstract

Objective: To investigate the role of cyclophilin A (CypA) and CD147 in the process of skin aging.

Methods: Twenty cases of tissue samples from junior group(<15 years old), middle age group(30-40 years old)or old age group (>65 years old) were collected from photophobic and exposal parts of skin, respectively. Immunohistochemistry (IHC) and in situ hybridization (ISH) were carried out to semi-quantitatively detect the expression level of CyPA and CD147.

Results: IHC demonstrated that both CyPA and CD147 were expressed in both photophobic and exposal parts of normal human skin in all 3 groups. The expression levels of both CyPA and CD147 were increased with increase in age. There were significant differences in both CyPA and CD147 expression among 3 groups (P<0.05). CyPA and CD147 were also positively correlated in all 3 groups. Similar results were achieved by ISH.

Conclusion: The interaction between CD147 and CyPA might play an important role in the process of skin aging.

PubMed Disclaimer

Publication types

LinkOut - more resources