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Comparative Study
. 2011 Sep 1;104(3):292-8.
doi: 10.1002/jso.21931. Epub 2011 Apr 4.

Outcomes of hepatic resection for huge hepatocellular carcinoma (≥ 10 cm in diameter)

Yo-ichi Yamashita  1 , Akinobu Taketomi, Ken Shirabe, Shinichi Aishima, Eiji Tsuijita, Kazutoyo Morita, Hiroto Kayashima, Yoshihiko Maehara
Affiliations
Comparative Study

Outcomes of hepatic resection for huge hepatocellular carcinoma (≥ 10 cm in diameter)

Yo-ichi Yamashita et al. J Surg Oncol. .

Abstract

Background: The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm.

Methods: Between 1995 and 2007, fifty-three patients with HCC ≥ 10 cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n = 12). Surgical results for HCC ≥ 10 cm were compared to those of patients with HCC < 10 cm (n = 412). The independent poor prognostic factors of the patients with HCC ≥ 10 cm were identified.

Results: Overall survival was significantly better in patients with hepatic resection for HCC ≥ 10 cm than in those with non-surgical treatment (P < 0.01). Survival rates of patients with hepatic resection for HCC ≥ 10 cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC ≥ 10 cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion.

Conclusion: Hepatic resections for HCC ≥ 10 cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC ≥ 10 cm in T4 appear to be critical.

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