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Review
. 2011 Aug;57(2):191-8.
doi: 10.1002/pbc.23114. Epub 2011 Apr 4.

Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients

L Lee Dupuis  1 , Sabrina Boodhan, Lillian Sung, Carol Portwine, Richard Hain, Patricia McCarthy, Mark Holdsworth; Pediatric Oncology Group of Ontario
Affiliations
Review

Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients

L Lee Dupuis et al. Pediatr Blood Cancer. 2011 Aug.

Abstract

This guideline provides clinicians caring for children with an approach to assessing the acute emetogenic potential of antineoplastic therapies. It was developed by an international, inter-professional panel of clinicians and researchers using AGREE and CAN-ADAPTE methods. The emetogenicity of antineoplastic agents was evaluated and ranked as high, moderate, low, or minimal. The emetogenicity of multiple-agent and multiple-day antineoplastic therapy was also classified. Gaps in the evidence used to underpin the guideline recommendations were identified. The contribution of this guideline to the prevention of antineoplastic-induced nausea and vomiting in individual children about to receive antineoplastic therapy requires prospective evaluation.

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Conflict of interest statement

Conflict of Interest Statement:

The authors declare no conflicts of interest.

Figures

Figure 1:
Figure 1:
Chemotherapy emetogenicity classification algorithm
Figure 2:
Figure 2:
Flow diagram Depicting Study Identification, Selection and Reasons for Exclusion
See this image and copyright information in PMC

References

    1. Patel P, Robinson PD, Thackray J, et al. Guideline for the prevention of acute chemotherapy-induced nausea and vomiting in pediatric cancer patients: A focused update. Pediatr Blood Cancer. 2017;64(10). - PubMed
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    1. Dupuis LL, Sung L, Molassiotis A, Orsey AD, Tissing W, van de Wetering M. 2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children. Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer. 2017;25(1):323–331. - PubMed
    1. Dupuis LL, Boodhan S, Holdsworth M, et al. Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Pediatr Blood Cancer. 2013;60(7):1073–1082. - PubMed
    1. Dupuis LL, Robinson PD, Boodhan S, et al. Guideline for the prevention and treatment of anticipatory nausea and vomiting due to chemotherapy in pediatric cancer patients. Pediatr Blood Cancer. 2014;61(8):1506–1512. - PubMed

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