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. 2009 Jun;7(1):14-9.
doi: 10.5049/EBP.2009.7.1.14. Epub 2009 Jun 30.

Expression of rh glycoproteins in the Mammalian kidney

Ki-Hwan Han  1 , Hye-Young Kim, I David Weiner
Affiliations

Expression of rh glycoproteins in the Mammalian kidney

Ki-Hwan Han et al. Electrolyte Blood Press. 2009 Jun.

Abstract

Ammonia metabolism is a fundamental process in the maintenance of life in all living organisms. Recent studies have identified ammonia transporter family proteins in yeast (Mep), plants (Amt), and mammals (Rh glycoproteins). In mammalian kidneys, where ammonia metabolism and transport are critically important for the regulation of systemic acid-base homeostasis, basolateral Rh B glycoprotein and apical/basolateral Rh C glycoprotein are expressed along the distal nephron segments. Data from experimental animal models and knockout mice suggest that the Rh glycoproteins appear to mediate important roles in urinary ammonia excretion.

Keywords: ammonia; kidney; kidney tubules, collecting.

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Figures

Fig. 1
Fig. 1
Basolateral Rh B glycoprotein (Rhbg) immunoreactivity is present in the majority of cortical collecting duct cells (arrows) but is absent in occasional cells (arrowhead).
Fig. 2
Fig. 2
Rh C glycoprotein (Rhcg) immunoreactivity is observed in both apical and basolateral membrane (arrow) in the rat cortical collecting duct.
See this image and copyright information in PMC

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