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. 2011 Feb;11(2):81.
doi: 10.1038/nri2922.

Immunometabolism: an emerging frontier

Diane Mathis  1 , Steven E Shoelson
Affiliations

Immunometabolism: an emerging frontier

Diane Mathis et al. Nat Rev Immunol. 2011 Feb.

Abstract

Immunometabolism is an emerging field of investigation at the interface between the historically distinct disciplines of immunology and metabolism. Accelerating interest in this area is being fuelled by the obesity epidemic and the relatively recent realization that obesity affects the immune system and promotes inflammation, and that obesity-induced inflammation potentially promotes a variety of chronic conditions and diseases. The multilevel interactions between the metabolic and immune systems suggest pathogenic mechanisms that may underlie many of the downstream complications of obesity and offer substantial therapeutic promise.

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References

    1. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117:175–184. - PMC - PubMed
    1. Ouchi N, et al. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science. 2010;329:454–457. - PMC - PubMed
    1. Larsen CM, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med. 2007;356:1517–1526. - PubMed
    1. Larsen CM, et al. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care. 2009;32:1663–1668. - PMC - PubMed
    1. Goldfine AB, et al. Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes. Clin Transl Sci. 2008;1:36–43. - PMC - PubMed

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