Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 May;29(4):325-37.
doi: 10.3109/07357907.2011.554476.

Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer

Susanna V Ulahannan  1 , Julie R Brahmer
Affiliations
Review

Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer

Susanna V Ulahannan et al. Cancer Invest. 2011 May.

Abstract

Most patients with non-small cell lung cancer (NSCLC) present with advanced disease requiring systemic chemotherapy. Treatment with the antiangiogenic agent bevacizumab in combination with standard platinum-based doublet chemotherapy has been shown to improve outcomes in patients with advanced NSCLC. Several multitargeted antiangiogenic tyrosine kinase inhibitors (e.g., sorafenib, sunitinib, cediranib, vandetanib, BIBF 1120, pazopanib, and axitinib) are also being evaluated in combination with standard chemotherapy. Here we review current clinical data with combination therapy involving antiangiogenic agents and cytotoxic chemotherapy in patients with advanced NSCLC.

PubMed Disclaimer

References

    1. American Cancer Society. Atlanta, GA: Amer ican Cancer Society, Inc; 2009. Cancer Facts & Figures, 2009.
    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Tnun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59(4):225–249. - PubMed
    1. Juergens R, Brahmer J. Targeting the epidermal growth factor receptor in non-small-cell lung cancer: who, which, when, and how? Curr Oncol Rep. 2007;9(4):255–264. - PubMed
    1. Stinchcombe TE, Socinski MA. Current treatments for advanced stage non-small cell lung cancer. Proc Am Thorac Soc. 2009;6(2):233–241. - PubMed
    1. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J, Johnson DH. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002;346(2):92–98. - PubMed

Publication types

MeSH terms