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Case Reports
. 2011 Nov;21(6):672-7.
doi: 10.1111/j.1750-3639.2011.00493.x. Epub 2011 May 30.

Common molecular cytogenetic pathway in papillary tumors of the pineal region (PTPR)

Angelika Gutenberg  1 , Almuth Brandis, Bujung Hong, Bastian Gunawan, Christina Enders, Inga-Marie Schaefer, Ralf Burger, Helmut Ostertag, Michael Gaab, Joachim K Krauss, Laszlo Füzesi
Affiliations
Case Reports

Common molecular cytogenetic pathway in papillary tumors of the pineal region (PTPR)

Angelika Gutenberg et al. Brain Pathol. 2011 Nov.

Abstract

Primary papillary tumors of the central nervous system and particularly the pineal region are rare. Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization Classification of Tumors of the Nervous System. Because of their rarity, further pheno- and genotypical observations as well as therapeutic experience are necessary to differentiate PTPR from other primary or secondary papillary tumors of this region. We herein present three cases of PTPR characterized by local recurrence in two of them. Primary and recurrent tumors were analyzed by immunohistochemistry and comparative genomic hybridization (CGH). From our results clonal chromosomal aberrations can be postulated which seem to be a feasible tool to differentiate PTPRs from other primary or secondary papillary tumors of this region.

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Figures

Figure 1
Figure 1
Immunohistochemical analyses in three patients with papillary tumor of the pineal region (PTPR). Abbreviations: CK8/18 = cytokeratin 8/18; EMA = epithelial membrane antigen; GFAP = glial fibrillary acidic protein; HE = hematoxylin and eosin; MAP2 = microtubule‐associated protein 2; NSE = neuron‐specific enolase.
See this image and copyright information in PMC

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