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Randomized Controlled Trial
. 2011 Jun;8(3):307-12.
doi: 10.1111/j.1742-481X.2011.00797.x. Epub 2011 Apr 7.

Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study

Hany Saad Setta  1 , Ahmed Elshahat, Khalid Elsherbiny, Karim Massoud, Ikram Safe
Affiliations
Randomized Controlled Trial

Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study

Hany Saad Setta et al. Int Wound J. 2011 Jun.

Abstract

Non healing diabetic foot ulcers and the resulting potential amputations present significant costs to the health care system and reduce patient quality of life. The goal of diabetic foot ulcer treatment is to obtain wound closure as expeditiously as possible. The use of platelet-rich plasma (PRP) to enhance wound healing has increased dramatically over the last decade. However, controversies exist in the literature regarding the added benefit of this procedure. The aim of this study is to investigate the efficiency of platelet releasate on the healing of chronic diabetic ulcers in comparison with platelet-poor plasma (PPP). This study included 24 patients with chronic diabetic ulcers. They were systematically randomised into two groups: PRP group (n = 12) and PPP group (n = 12). The results showed that healing in PRP group was significantly faster (P < 0·005). PRP enhances healing of chronic diabetic foot ulcers.

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Figures

Figure 1
Figure 1
Platelet‐rich plasma (PRP) preparation in a petri‐dish.
Figure 2
Figure 2
Diabetic foot ulcer before application of platelet‐rich plasma (PRP).
Figure 3
Figure 3
Diabetic foot ulcer shown in Figure 2 completely healed 10 weeks after application of platelet‐rich plasma (PRP).
Figure 4
Figure 4
Diabetic foot ulcer on sole before application of platelet‐poor plasma (PPP).
Figure 5
Figure 5
Diabetic foot ulcer shown in Figure 4 did not heal after 20 weeks of application of platelet‐poor plasma (PPP).
See this image and copyright information in PMC

References

    1. Mustoe TA. Dermal ulcer healing: advances in understanding. Presented at meeting: tissue repair and ulcer/wound healing: molecular mechanisms, therapeutic targets and future directions; 2005. Mar 17–18; Paris, France. URL http://www.pasteur.fr/applications/euroconf/tissuerepair/mustoe_abstract...
    1. Mustoe TA. Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg 2004;187: S65–70. - PubMed
    1. Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, Maroni M, Carabelli A. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci 2004;30:145–51. - PubMed
    1. Cross KJ, Mustoe TA. Growth factors in wound healing. Surg Clin North Am 2003;83:531–45. - PubMed
    1. Steed DL. Clinical evaluation of recombinant human platelet‐derived growth factors for the treatment of lower extremity diabetic ulcers. Diabetic Ulcer study group. J Vasc Surg 1995;21:71–8. - PubMed

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