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. 2011 Apr;17(4):584-91.
doi: 10.3201/eid1704.101115.

Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands

Judith Spijkerman  1 , Elske J M van Gils, Reinier H Veenhoven, Eelko Hak, Ed P F Yzerman, Arie van der Ende, Alienke J Wijmenga-Monsuur, Germie P J M van den Dobbelsteen, Elisabeth A M Sanders
Affiliations

Carriage of Streptococcus pneumoniae 3 years after start of vaccination program, the Netherlands

Judith Spijkerman et al. Emerg Infect Dis. 2011 Apr.

Abstract

To evaluate the effectiveness of the 7-valent pneumococcal conjugate vaccine (PCV7) program, we conducted a cross-sectional observational study on nasopharyngeal carriage of Streptococcus pneumoniae 3 years after implementation of the program in the Netherlands. We compared pneumococcal serotypes in 329 prebooster 11-month-old children, 330 fully vaccinated 24-month-old children, and 324 parents with age-matched pre-PCV7 (unvaccinated) controls (ages 12 and 24 months, n = 319 and n = 321, respectively) and 296 of their parents. PCV7 serotype prevalences before and after PCV7 implementation, respectively, were 38% and 8% among 11-month-old children, 36% and 4% among 24-month-old children, and 8% and 1% among parents. Non-PCV7 serotype prevalences were 29% and 39% among 11-month-old children, 30% and 45% among 24-month-old children, and 8% and 15% among parents, respectively; serotypes 11A and 19A were most frequently isolated. PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination.

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