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. 1978 Oct;305(1):1-4.
doi: 10.1007/BF00496998.

Site of naloxone-precipitated opiate withdrawal dissociates from that at which apomorphine reinitiates this phenomenon

R Schulz, J Bläsig, E Laschka, A Herz

Site of naloxone-precipitated opiate withdrawal dissociates from that at which apomorphine reinitiates this phenomenon

R Schulz et al. Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct.

Abstract

The site of action of naloxone to induce jumping in morphine tolerant/dependent rats appears to be dissociated from structures where apomorphine initiates its action to reinduce jumping in previously withdrawn animals. These findings suggest that dopaminergic pathways do not directly affect the neuronal circuit involved in withdrawal jumping behavior, but instead exert a facilitatory influence on neurons that become supersensitive during the state of withdrawal. Thus, an increased response to apomorphine during naloxone-precipitated opiate withdrawal does not necessarily imply a specific supersensitivity of the dopaminergic system.

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References

    1. Arzneimittelforschung. 1976;26(6):1104-6 - PubMed
    1. Nature. 1978 Mar 2;272(5648):73-5 - PubMed
    1. Psychopharmacologia. 1972;26(3):219-35 - PubMed
    1. Res Publ Assoc Res Nerv Ment Dis. 1968;46:226-46 - PubMed
    1. J Pharmacol Exp Ther. 1975 Dec;195(3):480-7 - PubMed