doi: 10.1016/0165-0327(90)90050-i.
A family study of lithium-responsive psychosis
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- PMID: 2147191
- DOI: 10.1016/0165-0327(90)90050-i
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A family study of lithium-responsive psychosis
J Affect Disord.
1990 Sep.
Abstract
Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P less than 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.
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