Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Apr 12;57(15):1587-90.
doi: 10.1016/j.jacc.2010.11.038.

Rationale for the use of the terms J-wave syndromes and early repolarization

Charles Antzelevitch  1 , Gan-Xin Yan, Sami Viskin
Affiliations
Comment

Rationale for the use of the terms J-wave syndromes and early repolarization

Charles Antzelevitch et al. J Am Coll Cardiol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Different manifestations of early repolarization. Each panel shows transmembrane action potentials recorded from the epicardial and endocardial regions of an arterially-perfused canine left ventricular wedge and a transmural ECG simultaneously recorded. Under the conditions indicated, the four panels illustrate the cellular basis for a J point elevation, a distinct J wave, slurring of the terminal part of the QRS and combined J wave, J point and ST segment elevation.
Figure 2
Figure 2
Male predominance of the Brugada phenotype in males. Each panel shows action potentials simultaneously recorded from 2 epicardial and 1 endocardial site of male or female RV wedge preparations, together with a transmural ECG. A: The addition of a potent sodium and calcium channel blocking agent (terfenadine, 5 uM) induces a heterogeneous loss of action potential dome, ST-segment elevation, and phase 2 reentry (arrow) in a male RV wedge preparation. B: The same concentration of terfenadine fails to induce as pronounced a Brugada phenotype in a female RV wedge preparation. C: Development of polymorphic VT triggered by spontaneous phase 2 reentry in a male preparation. D: Incidence of phase 2 reentry in male (6 of 7) vs female (2 of 7) RV wedge preparations when perfused with 5 uM terfenadine for up to 2 hours. Modified from (27), with permission.
Figure 3
Figure 3
Rate-dependence of the epicardial notch and J wave under hypothermic conditions. Shown are action potential recordings from an endocardial and two epicardial sites of a coronary-perfused wedge preparation together with a pseudo ECG.
Figure 4
Figure 4
Hypothermia-induced J wave. Each panel shows transmembrane action potentials from the epicardial and endocardial regions of an arterially-perfused canine left ventricular wedge and a transmural ECG simultaneously recorded. A: At 36°C the action potential notch in LV epicardium is relatively small and much of the J wave is buried in the QRS, manifesting as a J point elevation (arrow). B: A decrease in the temperature of the coronary perfusate to 29°C results in a slowing of transmural conduction and a dramatic increase in the amplitude and width of the action potential notch in epicardium but not endocardium, leading to the development of a transmural voltage gradient that manifests as a prominent J wave on the ECG (arrow). (Modified from Yan GX, Antzelevitch C (7), with permission)
See this image and copyright information in PMC

Comment on

References

    1. Antzelevitch C, Yan GX. J wave syndromes. Heart Rhythm. 2010;7:549–58. - PMC - PubMed
    1. Wasserburger RH, Alt WJ. The normal RS-T segment elevation variant. Am J Cardiol. 1961;8:184–92. - PubMed
    1. Mehta MC, Jain AC. Early repolarization on scalar electrocardiogram. Am J Med Sci. 1995;309:305–11. - PubMed
    1. Gussak I, Antzelevitch C. Early repolarization syndrome: clinical characteristics and possible cellular and ionic mechanisms. J Electrocardiol. 2000;33:299–309. - PubMed
    1. Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST segment elevation. Circulation. 1999;100:1660–6. - PubMed

Publication types