Autophagy in Ras-induced malignant transformation: fatal or vital?
- PMID: 21474062
- DOI: 10.1016/j.molcel.2011.03.003
Autophagy in Ras-induced malignant transformation: fatal or vital?
Abstract
In this issue of Molecular Cell, Elgendy et al. suggest that Ras-induced autophagy may kill tumor cells on the verge of oncogenic transformation, providing a contrast to recent reports indicating that autophagy is required for optimal growth of Ras-driven cancers.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival.Mol Cell. 2011 Apr 8;42(1):23-35. doi: 10.1016/j.molcel.2011.02.009. Epub 2011 Feb 25. Mol Cell. 2011. PMID: 21353614
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