iPSCs: induced back to controversy

Athanasia D Panopoulos¹, Sergio Ruiz, Juan Carlos Izpisua Belmonte

Affiliations

PMID: 21474093
DOI: 10.1016/j.stem.2011.03.003

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Comment

iPSCs: induced back to controversy

Athanasia D Panopoulos et al. Cell Stem Cell. 2011.

Free article

. 2011 Apr 8;8(4):347-8.

doi: 10.1016/j.stem.2011.03.003.

Authors

Athanasia D Panopoulos¹, Sergio Ruiz, Juan Carlos Izpisua Belmonte

Affiliation

¹ Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, CA 92037, USA.

PMID: 21474093
DOI: 10.1016/j.stem.2011.03.003

Abstract

Several recent reports (Mayshar et al., 2010; Laurent et al., 2011; Lister et al., 2011; Gore et al., 2011; Hussein et al., 2011) uncover genetic and epigenetic alterations in induced pluripotent stem cells, stimulating debate about their future. However, will these important findings really impact what we hope to gain?

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Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.
Mayshar Y, Ben-David U, Lavon N, Biancotti JC, Yakir B, Clark AT, Plath K, Lowry WE, Benvenisty N. Mayshar Y, et al. Cell Stem Cell. 2010 Oct 8;7(4):521-31. doi: 10.1016/j.stem.2010.07.017. Cell Stem Cell. 2010. PMID: 20887957
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.
Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J, Izpisua Belmonte JC, Murry C, Keirstead HS, Park HS, Schmidt U, Laslett AL, Muller FJ, Nievergelt CM, Shamir R, Loring JF. Laurent LC, et al. Cell Stem Cell. 2011 Jan 7;8(1):106-18. doi: 10.1016/j.stem.2010.12.003. Cell Stem Cell. 2011. PMID: 21211785 Free PMC article.
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.
Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O'Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR. Lister R, et al. Nature. 2011 Mar 3;471(7336):68-73. doi: 10.1038/nature09798. Epub 2011 Feb 2. Nature. 2011. PMID: 21289626 Free PMC article.
Copy number variation and selection during reprogramming to pluripotency.
Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, Bazett-Jones DP, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T. Hussein SM, et al. Nature. 2011 Mar 3;471(7336):58-62. doi: 10.1038/nature09871. Nature. 2011. PMID: 21368824
Somatic coding mutations in human induced pluripotent stem cells.
Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Gore A, et al. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. Nature. 2011. PMID: 21368825 Free PMC article.

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iPSCs: induced back to controversy

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iPSCs: induced back to controversy

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