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Comment
. 2011 Apr 8;8(4):354-6.
doi: 10.1016/j.stem.2011.03.006.

Blocking HIF1α activity eliminates hematological cancer stem cells

Ben S Lam  1 , Gregor B Adams
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Blocking HIF1α activity eliminates hematological cancer stem cells

Ben S Lam et al. Cell Stem Cell. .
Free article

Abstract

Selective targeting of cancer stem cells (CSCs) has the potential to prevent cancer relapse. Wang et al. (2011) report that hypoxia-inducible factor 1α (HIF1α) represses Notch signaling to maintain CSC subsets from lymphoma, and that blocking HIF1α activity eliminates lymphoma and human acute myeloid leukemia (AML) CSCs.

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