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Case Reports
. 2011 Feb 16;4(1):88-95.
doi: 10.1159/000324717.

Pure small cell carcinoma of the prostate: a case report and literature review

Antonio Capizzello  1 , Evangelia Peponi, Nafsika Simou, Dimitrios Ntaskagiannis, Ifigenia Tasiou, Sevasti Kamina, Periklis Tsekeris
Affiliations
Case Reports

Pure small cell carcinoma of the prostate: a case report and literature review

Antonio Capizzello et al. Case Rep Oncol. .

Abstract

Primary small cell carcinoma of the prostate (SCPCa) is a rare pathologic entity with unique clinical features and a poor prognosis. We present a case of a patient diagnosed with pure SCPCa treated with a combined chemo-radiotherapeutic approach. Pathological findings showed that the neoplastic cells exhibited positivity for pancytokeratin, synaptophysin, thyroid transcription factor-1 and CD56. Immunostaining for prostate-specific antigen was negative, while serum prostate-specific antigen was within normal limits. We review the available literature to gain additional information about diagnosis, treatment and prognosis of pure SCPCa.

Keywords: Neuroendocrine differentiation; Prostate cancer; Small cell carcinoma.

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Figures

Fig. 1
Fig. 1
HE staining (original magnification ×400).
Fig. 2
Fig. 2
Immunostaining for CD56 (original magnification ×400).
See this image and copyright information in PMC

References

    1. Wenk RE, Bhagavan BS, Levy R, Miller D, Weisburger W. Ectopic ACTH, prostatic oat cell carcinoma, and marked hypernatremia. Cancer. 1977;40:773–778. - PubMed
    1. Palmgren JS, Karavadia SS, Wakefield MR. Unusual and underappreciated: small cell carcinoma of the prostate. Semin Oncol. 2007;34:22–29. - PubMed
    1. di Sant'Agnese PA. Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implications. Cancer. 1992;70(1 suppl):254–268. - PubMed
    1. Petraki C, Vaslamatzis M, Petraki K, Revelos K, Alevizopoulos N, Papanastasiou P, Gregorakis A. Prostate cancer with small-cell morphology: an immunophenotypic subdivision. Scand J Urol Nephrol. 2005;39:455–463. - PubMed
    1. Spiess PE, Pettaway CA, Vakar-Lopez F, Kassouf W, Wang X, Busby JE, Do KA, Davuluri R, Tannir NM. Treatment outcomes of small cell carcinoma of the prostate: a single-center study. Cancer. 2007;110:1729–1737. - PubMed

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