[Evaluation of the effects of verapamil, flunarizine, diltiazem, nimodipine and placebo in the prevention of hemicrania. A double-blind randomized cross-over study]

Abstract

Notwithstanding progress in the prophylactic treatment of migraine, the available therapies are often inefficient and unsatisfactory. In this study, 50 patients suffering for at least one year from the classic or common type migraine and treated with calcium-antagonists: Verapamil, Flunarizine, Diltiazem, Nimodipine, as well as placebo, were studied. 34 patients completed the study. All of the calcium-antagonists studied resulted efficacious in the prophylaxis of migraine; however, more attention should be paid to Flunarizine since this substance, in addition to its therapeutic efficacy, also has the advantages of a single daily dose which makes it the drug of choice in the prophylaxis of vasomotor migraine.