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Review
. 2010 Jan;25(1):61-74.
doi: 10.1007/s00467-008-1020-x.

Mechanism of cellular rejection in transplantation

Elizabeth Ingulli  1
Affiliations
Review

Mechanism of cellular rejection in transplantation

Elizabeth Ingulli. Pediatr Nephrol. 2010 Jan.

Abstract

The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimulation, memory T cells, T cell migration, and their role in both acute and chronic graft destruction. An in depth understanding of the cellular mechanisms that result in both acute and chronic allograft rejection will provide new strategies and targeted therapeutics capable of inducing long-lasting, allograft-specific tolerance.

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Figures

Fig. 1
Fig. 1
Two distinct pathways of allorecognition. a Direct pathway of allorecognition. Dendritic cells migrate from the graft to secondary lymphoid tissues to activate T cells. b Indirect pathway of allorecognition. Graft proteins are processed by recipient dendritic cells and presented to T cells. APC Antigen-presenting cell, TCR T cell receptor, MHC major histocompatibility complex
Fig. 2
Fig. 2
DNA microarray analysis DNA from experimental samples is purified and fluorescently labeled and then hybridized to immobilized probes on the array to determine alterations in gene expression
See this image and copyright information in PMC

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