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Comment
. 2011 Sep;72(3):518-20; author reply 521-3.
doi: 10.1111/j.1365-2125.2011.03983.x.

Evaluation of a morphine maturation model for the prediction of morphine clearance in children

Brian Anderson, Nick Holford
Comment

Evaluation of a morphine maturation model for the prediction of morphine clearance in children

Brian Anderson et al. Br J Clin Pharmacol. 2011 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Predicted and observed clearance in 75 neonates (GA < 37 weeks) based on literature cited by Mahmood [1]
Figure 2
Figure 2
Mahmood [1]Figure 1 showing predicted and observed clearances in 75 neonates. There seem to be points missing at observed clearances around 8–11 ml min−1
Figure 3
Figure 3
Predicted and observed clearance in 144 neonates and children (age ≤ 5 PNA years) found in the literature cited by Mahmood [1]. Circled symbols refer to clearance estimates in the original publication that the original authors identified as being ‘divergent’. Comparison of the figures suggests Mahmood did not include these values
Figure 4
Figure 4
Mahmood [1]Figure 2 showing predicted and observed clearances in 147 neonates and children. There seem to be points missing at observed clearances greater than 400 ml min−1
See this image and copyright information in PMC

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References

    1. Mahmood I. Evaluation of a morphine maturation model for the prediction of morphine clearance in children: how accurate is the predictive performance of the model? Br J Clin Pharmacol. 2011;71:88–94. - PMC - PubMed
    1. Anand KJS, Anderson BJ, Holford NHG, Hall RW, Young T, Barton BA. Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial. Br J Anaesth. 2008;10:680–9. - PMC - PubMed
    1. FDA. Guidance for Industry. Pharmacokinetics in patients with impaired hepatic function: study design, data analysis, and impact on dosing and labeling. 2003. Available at http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformati... (last accessed 20 November 2010.
    1. Sheiner LB, Beal SL. Some suggestions for measuring predictive performance. J Pharmacokinet Biopharm. 1981;9:503–12. - PubMed
    1. Dahlström B, Bolme P, Feychting H, Noack G, Paalzow L. Morphine kinetics in children. Clin Pharmacol Ther. 1979;26:354–65. - PubMed

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