Processive ubiquitin chain formation by the anaphase-promoting complex
- PMID: 21477659
- PMCID: PMC3201729
- DOI: 10.1016/j.semcdb.2011.03.009
Processive ubiquitin chain formation by the anaphase-promoting complex
Abstract
Progression through mitosis requires the sequential ubiquitination of cell cycle regulators by the anaphase-promoting complex, resulting in their proteasomal degradation. Although several mechanisms contribute to APC/C regulation during mitosis, the APC/C is able to discriminate between its many substrates by exploiting differences in the processivity of ubiquitin chain assembly. Here, we discuss how the APC/C achieves processive ubiquitin chain formation to trigger the sequential degradation of cell cycle regulators during mitosis.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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