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Review
. 2011 Sep;28(5):435-47.
doi: 10.1016/j.nbt.2011.03.012. Epub 2011 Apr 6.

Analysis of the antibody structure based on high-resolution crystallographic studies

Jo Erika T Narciso  1 , Iris Diana C Uy, April B Cabang, Jenina Faye C Chavez, Juan Lorenzo B Pablo, Gisela P Padilla-Concepcion, Eduardo A Padlan
Affiliations
Review

Analysis of the antibody structure based on high-resolution crystallographic studies

Jo Erika T Narciso et al. N Biotechnol. 2011 Sep.

Abstract

High-resolution structures of liganded and unliganded antibody molecules were analyzed in terms of the interaction between the antibody with ligand, between the residues in the contact between the variable domains, and between the framework and the complementarity-determining regions of the antibody. The solvent accessibilities of the residues in the variable domains were also analyzed. The structural information is useful in the engineering of antibodies for therapeutic and other purposes.

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