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. 2011 Jun;24(2):63-6.
doi: 10.1177/0891988711402325. Epub 2011 Apr 8.

ABCB1 genotype and CSF beta-amyloid in Alzheimer disease

R Kohen  1 , J B Shofer, O Korvatska, E C Petrie, L Y Wang, G D Schellenberg, E R Peskind, C W Wilkinson
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ABCB1 genotype and CSF beta-amyloid in Alzheimer disease

R Kohen et al. J Geriatr Psychiatry Neurol. 2011 Jun.

Abstract

The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found.

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