Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul-Aug;115(4):267-276.
doi: 10.6028/jres.115.020. Epub 2010 Aug 1.

In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements

Shozo Takagi  1 , Stan Frukhtbeyn, Laurence C Chow, Akiyoshi Sugawara, Kenji Fujikawa, Hidehiro Ogata, Makoto Hayashi, Binnai Ogiso
Affiliations

In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements

Shozo Takagi et al. J Res Natl Inst Stand Technol. 2010 Jul-Aug.

Abstract

This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Experimental procedure of the animal study.
Fig. 2
Fig. 2
Schematic drawing of the pocket created in back area of rat.
Fig. 3
Fig. 3
Grafting procedure of the experiment.
Fig. 4
Fig. 4
Powder x-ray diffraction patterns of CPC0 and FA-CPCs: (a) CPC0, (b) FA-CPC1, (c) FA-CPC2 and (d) FA-CPC3.
Fig. 5
Fig. 5
Surface morphology of CPC0 and FA-CPC3 specimens: (A) flat surface of CPC0, (B) fractured surface of CPC0, (C) flat surface of FA-CPC3 and (D) fractured surface of FA-CPC3.
Fig. 6
Fig. 6
Histopathological features of CPC0 and FA-CPCs. (A) CPC0, (B) FA-CPC1, (C) FA-CPC2, and (D) FA-CPC3. Implanted material (IM), Fibrous Connective Tissue (FCT), Giant Cell (GC), Granuation Cell (GT), Undecalcified Material (UM), and Infiltrated Cell (IC).
See this image and copyright information in PMC

References

    1. Brown WE, Chow LC. A new calcium phosphate setting cement. J Dent Res. 1983;62(Spec. Iss.) Abst. No. 207.
    1. Sugawara A, Kusama K, Nishimura S, Nishiyama M, Ohashi M, Moro I, Chow LC, Takagi S. Biocompatibility and osteoconductivity of calcium phosphate cement. J Dent Res. 1990;69(Spec. Iss.) Abst. No. 1628.
    1. Chow LC, Takagi S, Costantino PD, Friedman CD. Self-setting calcium phosphate cements. Mater Res Soc Symp Proc. 1991;179:3–24.
    1. Sugawara A, Nishiyama M, Kusama K, Moro I, Nishimura S, Kudo I, Chow LC, Takagi S. Histopathological reactions of calcium phosphate cement. Dent Mater J. 1992;11:11–16. - PubMed
    1. Sugawara A, Fujikawa K, Kusama K, Nishiyama M, Murai S, Takagi S, Chow LC. Histopathologic reaction of calcium phosphate cement for alveolar ridge augmentation. J Biomed Mater Res. 2002;61:47–52. - PubMed

LinkOut - more resources