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. 2011 Apr 5:3:RRN1225.
doi: 10.1371/currents.RRN1225.

Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease

Stephen Oakeshott  1 , Fuat Balci, Igor Filippov, Carol Murphy, Russell Port, David Connor, Ahmad Paintdakhi, Joseph Lesauter, Liliana Menalled, Sylvie Ramboz, Seung Kwak, David Howland, Rae Silver, Dani Brunner
Affiliations

Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease

Stephen Oakeshott et al. PLoS Curr. .

Abstract

Huntington's disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD.

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