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Review
. 2011 Apr;44 Suppl 1(Suppl 1):55-9.
doi: 10.1111/j.1365-2184.2010.00728.x.

Insights into the biology of cord blood stem/progenitor cells

H E Broxmeyer  1
Affiliations
Review

Insights into the biology of cord blood stem/progenitor cells

H E Broxmeyer. Cell Prolif. 2011 Apr.

Abstract

Objectives: To review information on cord blood banking and transplantation with respect to the author's studies, and in context of this field of investigation.

Results: Cord blood transplantation has been successfully used to treat a number of malignant and non-malignant disorders. However, this technique is still associated with limited numbers of cells for transplantation, and with delayed engraftment of neutrophils and platelets. The field of cord blood transplantation will benefit from enhanced and mechanistically based information on haematopoietic stem cell function and potential means to enhance its effectiveness are reviewed. This includes notions concerning possibility of retrieving more cells from the placenta and cord blood, to expand haematopoietic stem cells ex vivo and to increase efficiency of homing and engraftment of these cells. Also discussed are cryopreservation and long-term storage of cord blood haematopoietic and progenitor cells, and new laboratory findings and animal studies for non-haematopoietic uses of cord blood.

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References

    1. Gluckman E, Broxmeyer HE, Auerbach AD, Friedman HS, Douglas GW, Devergie A et al. (1989) Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical‐cord blood from an HLA‐identical sibling. N. Engl. J. Med. 321, 1174–1178. - PubMed
    1. Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D et al. (1989) Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc. Natl. Acad. Sci. USA 86, 3828–3832. - PMC - PubMed
    1. Broxmeyer HE, Kurtzberg J, Gluckman E, Auerbach AD, Douglas G, Cooper S et al. (1991) Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation. Blood Cells 17, 313–329. - PubMed
    1. Broxmeyer HE (1997) Introduction: past, present and future of cord blood transplantation. In: Broxmeyer HE, ed. Cellular Characteristics of Cord Blood and Cord Blood Transplantation, pp. 1–11. Bethesda, MD, USA: Amer. Assoc. Blood Banking.
    1. Broxmeyer HE (2000) Introduction. Cord blood transplantation: looking back and to the future. In: Cohen SBA, Gluckman E, Rubinstein P, Madrigal JA, eds. Cord Blood Characteristics: Role in Stem Cell Transplantation, pp. 1–12. London, UK: M. Dunitz.

MeSH terms