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Case Reports
. 2011 Aug;38(4):285-6.
doi: 10.1111/j.1744-313X.2011.01007.x. Epub 2011 Apr 11.

Detection of A B acute lymphoblastic leukaemia blast-specific mutation in HLA-B*39:01

P Venigová  1 , P Jindra, V Koza
Affiliations
Case Reports

Detection of A B acute lymphoblastic leukaemia blast-specific mutation in HLA-B*39:01

P Venigová et al. Int J Immunogenet. 2011 Aug.

Abstract

Human leucocyte antigen (HLA) modifications observed in blast cells in haematologic malignancies can play an important role in disease progression and its therapy. Here we describe an insertion/deletion mutation in the second exon of HLA-B*39:01 that occurred in the blast cells of a patient with B-ALL. This mutation was not present in the nonleukemic cells, in which HLA-B*39:01 was normally expressed.

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