Chromosome segregation: a kinetochore missing link is found
- PMID: 21481764
- DOI: 10.1016/j.cub.2011.02.026
Chromosome segregation: a kinetochore missing link is found
Abstract
During mitosis the kinetochore assembles on centromeric chromatin. The component that connects the chromatin-associated inner domain to the microtubule-binding outer domain has eluded researchers. Two new studies identify a conserved molecular linkage between the inner and outer kinetochore.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Comment on
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CENP-C is a structural platform for kinetochore assembly.Curr Biol. 2011 Mar 8;21(5):399-405. doi: 10.1016/j.cub.2011.02.005. Epub 2011 Feb 25. Curr Biol. 2011. PMID: 21353555
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Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.Curr Biol. 2011 Mar 8;21(5):391-8. doi: 10.1016/j.cub.2010.12.039. Epub 2011 Feb 25. Curr Biol. 2011. PMID: 21353556 Free PMC article.
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