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. 2011;66(2):217-20.
doi: 10.1590/s1807-59322011000200006.

Longitudinal study of Cystatin C in healthy term newborns

Ana Carolina de Albuquerque Cavalcanti Ferreira Novo  1 , Lilian Dos Santos Rodrigues Sadeck, Thelma Suely Okay, Clea Rodrigues Leone
Affiliations

Longitudinal study of Cystatin C in healthy term newborns

Ana Carolina de Albuquerque Cavalcanti Ferreira Novo et al. Clinics (Sao Paulo). 2011.

Abstract

Objective: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life.

Introduction: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function.

Methods: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L)and creatinine (rng/dl) were determined in the mother (Mo) and in the newborn at birth (Day-0), 3rd (Day-3), 7th(Day-7) and 28t>h(Day-28) days.

Statistics: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for a = 5% and a power test = 80% (p<0.05).

Results: Data from 21 newborns were obtained (mean + standard deviation): MoCystatin C=1.00 ± 0.20; Day-0 Cystatin C 1.70 ± 0.26; Day-3 Cystatin C = 1.51 ± 0.20; Day-7 Cystatin C = 1.54 ± 0.10; Day-28 Cystatin C = 1.51 ± 0.10. MoCystatin C was smaller than Day-0 Cystatin C (p < 0.001), while MoCreatinine was not different from Day-0 Creatinine. Cystatin C only decreased from Day-0 to Day-3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day-3 (p = 0.047) and Day-28 (p = 0.022) Cystatin C and Creatinine values.

Conclusion: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3rd day of life.

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Figures

Figure 1
Figure 1
NB blood pressure and post conceptual gestational age according to reference values of Zubrow.
Figure 2
Figure 2
Mean values of mother creatinine and cistatina C at birth and the newborn during the 1st month of life.
See this image and copyright information in PMC

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