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Review
. 2011;13(1):127-38.
doi: 10.31887/DCNS.2011.13.1/rjoffe.

Hormone treatment of depression

Russell T Joffe  1
Affiliations
Review

Hormone treatment of depression

Russell T Joffe. Dialogues Clin Neurosci. 2011.

Abstract
in English, Spanish, French

There is a well-established relationship between alterations of various hormonal systems and psychiatric disorders, both in endocrine and psychiatric patients. This has led to clinical and research studies examining the efficacy of the different hormones for treatment of depression. These data will be reviewed with particular regard to the thyroid, gonadal, pineal, and adrenal cortex hormones. The data generally provide limited, but varying evidence for the antidepressant efficacy of these hormones.

Existe una relación bien reconocida entre las alteraciones de varios sistemas hormonales y los trastornos psiquiátricos, tanto en pacientes con patología endocrina como psiquiátrica. Esto ha promovido estudios clínicos e investigaciones que examinan la eficacia de diferentes hormonas para el tratamiento de la depresión. Se revisará la información disponible especialmente para las hormonas tiroideas, gonadales, pineales y de la corteza adrenal. Los datos aportan evidencias en general limitadas y de eficacia antidepresiva variable para estas hormonas.

Il existe une relation bien établie entre les variations des différents systèmes hormonaux et les troubles psychiatriques, à la fois chez les patients souffrant de troubles psychiatriques et ceux souffrant de troubles endocriniens. Ces constatations ont conduit la réalisation d'études cliniques et fondamentales afin d'analyser l'efficacité des différentes hormones dans le traitement de la dépression. Les données disponibles seront présentées, avec un intérêt particulier pour les hormones thyroïdiennes, gonadiques, épiphysaires et cortico-surrénaliennes. Les résultats apportent des arguments généralement limités et fluctuants en ce qui concerne l'efficacité de ces hormones.

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