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. 2011 Jun 30;95(8):2494-8.
doi: 10.1016/j.fertnstert.2011.03.031. Epub 2011 Apr 12.

Insulin resistance influences central opioid activity in polycystic ovary syndrome

Alison Berent-Spillson  1 , Tiffany Love, Rodica Pop-Busui, MaryFran Sowers, Carol C Persad, Kathryn P Pennington, Aimee D Eyvazaddeh, Vasantha Padmanabhan, Jon-Kar Zubieta, Yolanda R Smith
Affiliations

Insulin resistance influences central opioid activity in polycystic ovary syndrome

Alison Berent-Spillson et al. Fertil Steril. .

Abstract

This pilot study describes a relationship between insulin resistance and μ-opioid neurotransmission in limbic appetite and mood-regulating regions in women with polycystic ovary syndrome (PCOS), suggesting that insulin-opioid interactions may contribute to behavioral and reproductive pathologies of PCOS. We found that [1] patients with PCOS who are insulin-resistant (n = 7) had greater limbic μ-opioid receptor availability (nondisplaceable binding potential) than controls (n = 5); [2] receptor availability was correlated with severity of insulin resistance; and [3] receptor availability normalized after insulin-regulating treatment.

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