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Review
. 2011 Apr;26(2):115-23.
doi: 10.1152/physiol.00049.2010.

Aldosterone paradox: differential regulation of ion transport in distal nephron

Juan Pablo Arroyo  1 , Caroline Ronzaud, Dagmara Lagnaz, Olivier Staub, Gerardo Gamba
Affiliations
Free article
Review

Aldosterone paradox: differential regulation of ion transport in distal nephron

Juan Pablo Arroyo et al. Physiology (Bethesda). 2011 Apr.
Free article

Abstract

The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K(+) balance.

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Comment in

  • Aldosterone paradox.
    Ming CH. Ming CH. Physiology (Bethesda). 2011 Oct;26(5):307; author reply 308. doi: 10.1152/physiol.00026.2011. Physiology (Bethesda). 2011. PMID: 22013188 No abstract available.

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