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. 1990 Oct 1;528(2):308-10.
doi: 10.1016/0006-8993(90)91672-4.

The effect of aging on the D1 dopamine receptors in human frontal cortex

J de Keyser  1 , J P De Backer, G Vauquelin, G Ebinger
Affiliations

The effect of aging on the D1 dopamine receptors in human frontal cortex

J de Keyser et al. Brain Res. .

Abstract

Dopaminergic pathways to the cerebral cortex may be involved in cognitive function. We examined the effect of aging on the D1 dopamine receptors, and their high-agonist affinity (RH) sites, in postmortem human frontal cortex (n = 32; age range, 19-88 years). With aging, there was a significant decrease in the densities of the D1 dopamine receptors, and their RH sites, in human frontal cortex. The age-related reduction of cortical dopaminergic neurotransmission might contribute to the decline in cognitive abilities of elderly persons.

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