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. 2011 Mar 25:3:103-6.
doi: 10.2147/CLEP.S17298.

Breast cancer associated with primary hyperparathyroidism: a nested case control study

Sophie Norenstedt  1 , Fredrik Granath, Anders Ekbom, Jonas Bergh, Mats Lambe, Jan Adolfsson, Fredrik Warnberg, Jan Zedenius, Inga-Lena Nilsson
Affiliations

Breast cancer associated with primary hyperparathyroidism: a nested case control study

Sophie Norenstedt et al. Clin Epidemiol. .

Abstract

Background: Primary hyperparathyroidism (pHPT) is associated with an increased risk of developing breast cancer, but little is known about the underlying factors. The aim of this study was to compare women with a history of pHPT and a reference population in terms of standard factors predictive of prognosis and response to therapy for breast cancer.

Methods: We analyzed data collected from the National Swedish Cancer Register and from two regional oncologic center registries. Seventy-one women with breast cancer and a history of parathyroid adenomectomy were compared with 338 matched controls with breast cancer only. Tumor size, stage, hormone receptor status, lymph node status, cause of death, and cumulative survival were analyzed.

Results: The mean age was 69 ± 11 years (95% confidence interval [CI]: 68-70) in both groups and the mean time interval between the parathyroid surgery and breast cancer diagnosis was 91 ± 68 months (95% CI: 72-111). There were no differences between the two groups regarding size, stage, lymph node metastases, or survival, but none of the cases with a history of pHPT were found in Stage III or IV.

Conclusion: In conclusion, factors predictive of prognosis and response to therapy in women with a history of pHPT and breast cancer are similar to those in breast cancer patients without pHPT.

Keywords: breast cancer; primary hyperparathyroidism; prognostic factors.

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Figures

Figure 1
Figure 1
Kaplan–Meier plots of breast cancer-specific survival in women with pHPT + breast cancer (cases) and women with breast cancer only (controls).
See this image and copyright information in PMC

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